IntraGraft® Bone Marrow
What is
IntraGraft® Bone Marrow
The selective aspiration of mesenchymal stromal cells (MSCs) from
bone marrow represents an advanced strategy in the field of autologous
regenerative medicine applied to sports medicine.
Bone Marrow Aspirate Concentrate (BMAC) is a cell suspension rich in
multipotent mesenchymal cells, hematopoietic cells,
immunomodulatory cytokines, and growth factors (including TGF-β,
PDGF, VEGF, IGF-1).
These biological components interact synergistically with the injured tissue microenvironment, exerting anti-inflammatory, trophic, and
regenerative effects, particularly at the osteoarticular, tendinous, and
musculo-ligamentous levels.
Bone Marrow Aspirate Concentrate (BMAC)
in Orthopedics & Traumatology
BMAC is indicated for the biological treatment of:
• Early to moderate osteoarthritis of the knee, hip, shoulder, and ankle
• Meniscal and cartilage lesions
• Chronic tendinopathies (e.g., Achilles, patellar, rotator cuff)
• Muscle injuries and volumetric muscle loss (VML)
• Carpal tunnel syndrome and entrapment neuropathies
• Osteoarthritis of the wrist and small joints
Clinical Benefits
• Anti-inflammatory
• Regenerative Effect
• Analgesic Effect
• Immunomodulatory Effect
• Functional Improvement
Centrifugation vs.
Mechanical Filtration
Mechanical separation preserves cell viability better than centrifugation. This enables the collection of bone marrow tissue rich in mesenchymal cells, ensuring better clinical outcomes and greater safety in regenerative medicine treatments.
Key Features of the
IntraGraft® Bone Marrow Technique
Targeted and minimally invasive harvesting
→ Selective aspiration from the iliac crest using dedicated needles, minimizing trauma and pain for the patient.
Selection of the marrow compartment
→ The hematopoietic compartment of the posterior iliac crest contains the highest concentration of mesenchymal stem cells and osteogenic progenitors.
Standardized protocol
→ Codified and repeatable technique, performable by orthopedic personnel with specific training.
High cell vitality concentrate
→ Use of closed-circuit systems for marrow concentration without aggressive centrifugation →preservation of cellular vitality.
Low risk profile
→ Minimal risk of infection, local complications, or adverse reactions → the concentrate is autologous and biocompatible.
Easy intraoperative or infiltrative application
→ BMAC can be directly injected or combined with scaffolds/bone substitutes in a versatile and targeted manner.
