Bibliography Table by Anatomical Region

    Regenerative medicine applied to Orthopedics & Traumatology relies on a growing number of high-level scientific publications.

    HIP

    Role of Autologous Micro-Fragmented Fat in Hip and Knee OA
    Authors: Paolo Trentani, Elena Meredi, Paola Zarantonello, Alessandro Gennai
    Year: 2024 (MDPI)
    Pathology: Osteoarthritis
    Findings: Functional improvement and pain reduction

    Is intra injection of autologous micro-fragmented adipose tissue effective in hip osteoarthritis? A three-year follow-up
    Authors: Simone Natali, Daniele Screpis, Michele Romeo, Stefano Magnanelli
    Year: 2022
    Pathology: Moderate hip osteoarthritis
    Findings: Significant clinical improvements

    Arthroscopic treatment of chondral defects in the hip: AMIC, MACI, microfragmented adipose tissue transplantation (MATT) and other options
    Authors: Eugenio Jannelli – Andrea Fontana
    Year: 2017 (SICOT)
    Pathology: Osteoarthritis
    Findings: Valid treatment option for cartilage repair

    Clinical use of autologous adipose-derived stromal vascular fraction cells for the treatment of hip osteoarthritis
    Authors: Yuma Onoi a, Tomoyuki Matsumoto a, Satoshi Sobajima b, Masanori Tsubosaka a, Shinya Hayashi a, Takehiko Matsushita a, Hideki Iwaguro b, Ryosuke Kuroda a
    Year: 2023
    Pathology: Osteoarthritis
    Findings: Symptom reduction

    Adipose Tissue Injections for Severe Hip Osteoarthritis: A Case Series
    Authors: David R Bakal1, Neal Varghis1 and Eugene Y Roh
    Year: 2022
    Pathology: Severe hip osteoarthritis
    Findings: Pain and function improvemen

    KNEE

    Current status of nanofat in the management of knee osteoarthritis
    Authors: Naveen Jeyaraman, Sandeep Shrivastava, VR Ravi, Arulkumar Nallakumarasamy, Madhan Jeyaraman
    Year: 2024 (PMC11752481)
    Pathology: Osteoarthritis
    Findings: Pain relief, functional improvement, good tolerability

    Autologous micro-fragmented adipose tissue injection… knee osteoarthritis: a case-series
    Authors: Arcangelo Russo, Gabriele Cortina, Vincenzo Condello, Marco Collarile, Roberto Orlandi, Riccardo Gianoli, Emanuele Giuliani & Vincenzo Madonna
    Year: 2023
    Pathology: Osteoarthritis
    Findings: Prolonged improvement in pain and joint function

    Adipose Tissue Stem Cells for Knee Arthritis and Cartilage Lesions
    Authors: Dimitrios Tsoukas, Christos Simos, Vasilliki Kalodimou
    Year: 2023
    Pathology: Arthritis and cartilage lesions
    Findings: Pain reduction, improved mobility

    Intra-articular injection of autologous fat tissue… chronic knee pain
    Authors: Bayram et al.
    Year: 2023 (JournalAgent)
    Pathology: Osteoarthritis
    Findings: Improved function and pain relief

    SHOULDER

    Clinical Assessment of NanoFat for Partial Rotator Cuff Tear
    Authors: Ronald B Barreto, Ricardo E R Silva Jr, Juliana M C Lira, Joao M M de A Santos,
    Bernard P R Barbosa and Jose F S D Lana, David Sadigursky
    Year: 2023
    Pathology: Partial rotator cuff tear
    Findings: Functional improvement and pain reduction

    Clinical use of autologous micro-fragmented fat progressively restores pain and function in shoulder osteoarthritis
    Authors: Heather Vinet-Jones , Kevin F Darr
    Year: 2020
    Pathology: Shoulder osteoarthritis
    Findings: Pain relief and improved joint function

    Outcomes after Micronized Fat Transfer for Glenohumeral Arthritis and RCT: A Case Series of 18 Shoulders
    Authors: D. M. Robinson, C. Eng, M. Mitchkash, A. S. Tenforde, J. Borg-Stein
    Year: 2023
    Pathology: Arthritis and rotator cuff tears
    Findings: Clinical improvement in pain and mobility

    Microfragmented adipose tissue in full-thickness supraspinatus tear
    Authors: John L Ferrell, Alanna Dodson, Joshua Martin
    Year: 2023
    Pathology: Full-thickness supraspinatus tear
    Findings: Pain and function improvement

    Role of ADSCs in Rotator Cuff Tears: from basic science to clinical application
    Authors: Fabrizio Mocini, Andrea Stefano Monteleone, Piero Piazza, Valentina Cardona, Valeria Vismara, Piermarco Messinese, Vincenzo Campana, Giuseppe Sircana, Giulio Maccauro, Maristella Francesca Saccomanno
    Year: 2020
    Pathology: Rotator cuff tears
    Findings: Functional recovery and pain relief

    FOOT & ANKLE

    Efficacy and Duration of Intra-Articular Autologous Micro-Fragmented Adipose Tissue
    in Athletes with Ankle Osteoarthritis: A 36-Month Follow-Up Study
    Authors: Venanzio Iacono, Simone Natali, Luca De Berardinis, Daniele Screpis
    Year: 2023
    Pathology: Ankle osteoarthritis
    Findings: Effective regenerative approach

    Autologous fat graft in foot calcaneal postsurgical chronic ulcer
    Authors: Luca Maione, Andrea Lisa, Valeriano Vinci, Valeria Bandi, Francesco Klinger, Marco Klinger
    Year: 2019
    Pathology: Postsurgical chronic ulcer
    Findings: Wound re-epithelialization and pain relief

    Annular lipoatrophy of the ankles treated by fat grafting: Case report and review of the literature
    Authors: B Nguyen-Khac, J B Leca, D Carre, D Coquerel-Beghin, I Auquit-Auckbur
    Year: 2015
    Pathology: Annular lipoatrophy
    Findings: Correction of cosmetic sequelae

    Contemporary Review: The Use of ADSCs in Pathologies of the Foot and Ankle
    Authors: Usuelli et al.
    Year: 2017
    Pathology: Tendinopathies, hallux rigidus, plantar fasciitis
    Findings: Pain relief and functional recovery

    Hallux rigidus treated with ADSCs: A case report
    Authors: Adriano Braile, Giuseppe Toro, Annalisa De Cicco, Antonio Benedetto Cecere, Fabio Zanchini, Alfredo Schiavone Panni
    Year: 2021
    Pathology: First MTP joint arthritis
    Findings: Symptom improvement and function recovery

    Adipose-derived stem cells in orthopaedic pathologies
    Authors: Federico Giuseppe Usuelli, Riccardo D’Ambrosi, Camilla Maccario, Cristian Indino, Luigi Manzi, Nicola Maffulli
    Year: 2018
    Pathology: Various orthopaedic conditions (Achilles tendinopathy, plantar fasciitis, hallux rigidus, ankle osteoarthritis, osteochondral lesions, cartilage injuries, soft tissue defects)
    Findings: Adipose-derived stem cells (ADSCs) showed pain relief, functional improvement, and regenerative effects across multiple musculoskeletal disorders. Considered a promising biological treatment; further randomized controlled trials are recommended.

    WRIST & HAND

    Evaluation of Adipose Cell-Based Therapies for the Treatment of Thumb Carpometacarpal Joint Osteoarthritis
    Authors: Eleni Karagergou, Theodora Ligomenou, Byron Chalidis, Dimitrios Kitridis, Sophia Papadopoulou, Panagiotis Givissis
    Year: 2022
    Pathology: Thumb carpometacarpal osteoarthritis
    Findings: Pain relief and improved hand function

    Autologous Fat Grafting in Hand Surgery: A Systematic Review
    Authors: Henderson, Brennon BS; Cushman, Caroline J. BS; Price, Ashley D. BS; Hoffpauir, Lauren A. BS; Jain, Neil MD; Hernandez, Evan J. MBA; Idicula, Anceslo MD, MS; MacKay, Brendan J. MD
    Year: 2025
    Pathology: Scleroderma, Dupuytren’s, burns, fingertip trauma
    Findings: Symptom relief and aesthetic enhancement

    Treatment of Recurrent Carpal Tunnel Syndrome with Fat Grafting
    Authors: Raysa Cabrejo, Alison Podsednik (The University of Texas Rio Grande Valley), Joseph Rosen
    Year: 2023
    Pathology: Recurrent carpal tunnel syndrome
    Findings: Improved symptoms and nerve decompression

    ELBOW

    Promising improvement of chronic lateral elbow tendinopathy by using adipose derived mesenchymal stromal cells: a pilot study
    Authors: Miguel Khoury, Montassar Tabben, Alejandro U Rolón, Lorena Levi, Karim Chamari, Pieter D’Hooghe
    Year: 2021
    Pathology: Chronic lateral epicondylitis
    Findings: Pain reduction and functional improvement using ADSCs

    Treatment of Lateral Epicondylosis using Allogeneic ADSCs : a pilot study
    Authors: Sang Yoon Lee, Won Kim, Chaiyoung Lim, Sun G Chung
    Year: 2015
    Pathology: Lateral epicondylosis
    Findings: Safe and effective over 1 year, reduced pain (VAS) and improved performance

    ADSC-Based Cell Therapies for Musculoskeletal Disorders: A Review of recent clinical trial
    Authors: Seahyoung Lee, Dong-Sik Chae, Byeong-Wook Song, Soyeon Lim, Sang Woo Kim, Il-Kwon Kim, Ki-Chul Hwang
    Year: 2021
    Pathology: Tendon disorders (including epicondylitis)
    Findings: Positive outcomes in tendon healing and pain reduction

    Effect of ADSC + PRP in Elbow Tendinopathy: Case Report
    Authors: Julien Freitag, Kiran Shah, James Wickham, Abi Tenen
    Year: 2020
    Pathology: Severe elbow tendinopathy
    Findings: Symptom relief with ADSCs combined with PRP