BMAC | Combination with other materials

    USE OF BONE MARROW ASPIRATE CONCENTRATE WITH HIGH MESENCHYMAL STROMAL CELL CONTENT (BMAC)

    Autologous bone marrow concentrate obtained through selective aspiration from hematopoietic bone marrow represents a biologically active source of mesenchymal stromal cells (MSCs), applicable in orthopedic, sports, and trauma-related regenerative medicine.

    Depending on its combination with osteoconductive biomaterials or bone grafts, BMAC isused in a wide range of clinical indications.

    Direct Use of BMAC
    (without combination with other materials)

    Clinical Indications:

    • Bone cysts (unicameral, aneurysmal): injection to stimulate endogenous osteogenesis and promote resolution of the cysticcavity
    • Degenerative joint diseases (intra-articularinjections):
    usedto modulate inflammation and improve the joint microenvironment
    • Chronic tendinopathies (Achilles, patellar, epicondylitis): applied to stimulate tendon regeneration via paracrine factor release
    • Degeneration of vertebral facet joints (low back pain):
    periarticular injection for trophic and analgesic effects

    BMAC combined with bone substitutes (synthetic or xenogenic biomaterials)

    Clinical Indications:

    • Spinalarthrodesis: combined use to promote bone fusion by increasing the osteogenic cellular component
    • Subchondral lesions (e.g., bone edema, osteochondritis): used for trabecular regeneration and stabilization of the subchondral segment
    • Peripheral joint arthrodesis (e.g., tibio-tarsal, interphalangeal): improved biological integration and reduced consolidation time

    BMAC combined with autologous bone

    Clinical Indications:

    • Osteonecrosis(femoral head, early stages): combined with core decompression to delay collapse progression.
    • Post-traumatic or degenerative subchondral lesions: stimulation of bone remodeling via enhanced osteogenic grafting.
    • Non union and delayed union: integration at non union sites to enhance regenerative potential.
    • Complexor high-energy fractures: biological support in patients with high risk of delayed healing